So, why have Buy Research Chemicals UK not stocked 5-IAI thus far? Well we've had this product listed as coming soon on our website since the end of April, way before most vendors had even heard of it and started to jump on the bandwagon.

In that time we've been sent and indeed encountered various samples of supposed "5-IAI" but none of them checked out, and certainly none of them were offered with any form of analysis, not even a proton NMR spectrograph. Since any genuine lab would as a matter of absolute routine perform an NMR analysis of their final product (as well as the intermediates), particularly a novel one that they'd never produced before to actually check that all had gone well with their decided synthesis route, then the absence of such analysis speaks volumes about the likelyhood of said samples being 5-IAI. Quite simply they weren't.

As such, it is our opinion that there isn't any genuine 5-IAI on the market right now. That's not a direct slight against any particular supplier who may be offering it at the moment, most are unwittingley duped by their wholesale suppliers. But since none of them to my knowledge have published even a basic analysis of their product then I wouldn't blame researchers for being sceptical as we are.

Well now we have been provided with a 5-IAI sample from a supplier, backed up with a proton NMR spectrograph. The spectrograph image is published below (forgive the unsightly watermarks, its sadly neccessary, also a higher resolution jpeg image can be provided upon email request) and is accompanied by the comments from an independent scientist (i.e. independent as in not on the payroll) who kindly took a look at it for us. Just a respectful reminder, please note that this blog post including the quoted scientific commentary is the copyright of Buy Research Chemicals UK, as is the NMR spectrograph which we've published with the permisson of our supplier. No reproduction or modification in any media is allowed without explicit prior written permission from us. If any reputable vendor wishes to know the source of this genuine 5-IAI then feel free to drop us an email and we'll point you in the right direction.




"The 5-IAI: quite an old NMR machine (100MHz?) - nevertheless it looks good to me, and reasonably pure. The large peak stems from the solvent change, they used MeOD, the water peak comes at ~4.9, probably together with the ammonium protons, assuming its hydrochloride, the about same shift but unequal pattern of the 2 CH2 proves the asymmetric nature of 5-IAI (contrary to the symmetric MDAI!), the CH is also there though not split as sharply because of the NH3+ neighbour (and probably because it's not a 300MHz machine); The aromats fit as well, two doublets (the H's on carbons 2 and 3) plus a singlet of the "lonely" H on C6- proves the right substitution. Of course one can't tell if the substitute is really Iodine from just this! And I'm only assuming the counterion to the NH3 is Chloride. Theoretically one could deduct the substituent with NMR tables but I'm unsure if they even exist for indans..."

So there we have it folks - on the basis of that positive analysis we're confident that at last real 5-IAI has been produced and it should be in stock around the 6th September! Keep an eye on my blog over the coming days for details of how to reserve one of 20 x 500mg samples that we will be giving to researchers for free. As with the free AMT samples there will be a question to answer and it will be a bit more challenging this time!

In the meantime, I can't say 100% that no-one else has genuine 5-IAI yet (and of course our supplier will be dealing with other vendors too, although my understanding is that we are the first to order), but I really hope that this starts a trend of suppliers publishing proper analysis' of their products. If they can't back up their claims for these new compounds, then please be wary.